abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

journal_title：European journal of clinical pharmacology

authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

更新日期：1984-01-01 00:00:00

abstract：:The metabolism of hydralazine in a group of slow acetylator patients with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects. There were no toxicologically significant difference in metabolite excretion between the groups which reached statistical significance, although t...

journal_title：European journal of clinical pharmacology

authors： Timbrell JA,Facchini V,Harland SJ,Mansilla-Tinoco R

更新日期：1984-01-01 00:00:00

abstract：:Plasma levels of canrenone and 'total metabolites' after base hydrolysis were compared in young and elderly subjects following single and multiple doses of spironolactone. After the initial dose on Day 1, plasma levels of canrenone and 'total metabolites' were higher in the young than in the elderly group, and signifi...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Bourne DW,Triggs EJ,Smithurst BA

更新日期：1984-01-01 00:00:00

abstract：:The influence of time of drug administration on pharmacokinetics of theophylline was studied both after ingestion of a sustained-release tablet, containing choline theophyllinate ( Zy 15061-S. R.; Teovent ; Sabidal ; ZYMA S.A.) and after intravenous infusion of aminophylline to eight healthy volunteers. Both drugs wer...

journal_title：European journal of clinical pharmacology

authors： Jonkman JH,van der Boon WJ,Balant LP,Schoenmaker R,Holtkamp A

更新日期：1984-01-01 00:00:00

abstract：:Ninety-six depressed outpatients from 5 centres were given viloxazine 200-400 mg/day. The treatment produced significant clinical improvement as evaluated by the Hamilton Rating Scale for Depression. Thirteen patients dropped-out because of possible side effects. Many untoward symptoms were described by all the patien...

journal_title：European journal of clinical pharmacology

authors： Maistrello I,Grassi G,Bertolino A,Valerio P,Pistollato G,Soverini S

更新日期：1983-01-01 00:00:00

abstract：:The disposition of oral metoprolol was studied in 5 women during the last trimester of pregnancy and 3 to 5 months after delivery. After a single oral dose of 100 mg the individual peak plasma concentration in the pregnant state was only 20-40% of that after pregnancy. The plasma half-lives of metoprolol were about th...

journal_title：European journal of clinical pharmacology

authors： Högstedt S,Lindberg B,Rane A

更新日期：1983-01-01 00:00:00

abstract：:Seven patients with acutely elevated diastolic blood pressure (DBP greater than or equal to 135 mmHg) were treated with repeated injections of diazoxide 1 mg/kg body weight i.v. at 10-min intervals. If the DBP was not reduced to 110 mmHg or less after 5 injections, a dose of 5 mg/kg was given. Serum diazoxide (total a...

journal_title：European journal of clinical pharmacology

authors： McNair A,Andreasen F,Nielsen PE

更新日期：1983-01-01 00:00:00

abstract：:Procaine esterase activity in plasma from patients with renal failure is decreased by 40%. Since cyanate is formed from urea and readily carbamylates certain blood proteins, a possible role for cyanate in the depression of plasma esterase activity in uraemic patients was considered. However, in vitro carbamylation of ...

journal_title：European journal of clinical pharmacology

authors： Calvo R,Carlos R,Erill S

更新日期：1983-01-01 00:00:00

abstract：:The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Möhrke W,Mutschler E

更新日期：1983-01-01 00:00:00

abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

journal_title：European journal of clinical pharmacology

authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

更新日期：1983-01-01 00:00:00

abstract：:The haemodynamic effects of prenalterol, a new beta-1 agonist, were studied in 10 patients with chronic heart failure. Following intravenous prenalterol infusions of 1 mg, 2.5 mg and 5 mg at 15 min intervals, oral slow release prenalterol 20 mg, 30 mg and 50 mg was given at 2 h intervals and then 50-100 mg bid for one...

journal_title：European journal of clinical pharmacology

authors： Sharpe DN,Coxon R

更新日期：1983-01-01 00:00:00

abstract：:Natural and synthetic steroids and mineralocorticoids were tested for their in vitro suppressive activity on phytohemagglutinin (PHA) stimulated lymphocytes. Three different (p less than 0.05) groups were identified. Methylprednisolone and betamethasone were very potent, dexamethasone, hydrocortisone and prednisolone ...

journal_title：European journal of clinical pharmacology

authors： Langhoff E,Ladefoged J

更新日期：1983-01-01 00:00:00

abstract：:Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous materna...

journal_title：European journal of clinical pharmacology

authors： Smith MT,Livingstone I,Eadie MJ,Hooper WD,Triggs EJ

更新日期：1983-01-01 00:00:00

abstract：:Guidelines presented previously for the analysis of plasma concentration versus time data for a drug exhibiting concentration-dependent plasma protein binding were successfully applied to the distributional parameters of a new cephalosporin, ceftriaxone. This approach provided several striking observations when the ph...

journal_title：European journal of clinical pharmacology

authors： McNamara PJ,Gibaldi M,Stoeckel K

更新日期：1983-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：:Since little is known of the number and types of binding sites on alpha 1-acid glycoprotein (AAG) and because drug-drug protein binding interactions often fail to fit a simple model, a study of the effect of 9 known AAG binding drugs on lidocaine free fraction (LFF) was performed. Serum was obtained from 10 healthy ma...

journal_title：European journal of clinical pharmacology

authors： Goolkasian DL,Slaughter RL,Edwards DJ,Lalka D

更新日期：1983-01-01 00:00:00

abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

journal_title：European journal of clinical pharmacology

authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

更新日期：1983-01-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：:The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight h...

journal_title：European journal of clinical pharmacology

authors： Gasic S,Korn A,Eichler HG,Oberhummer I,Zapotoczky HG

更新日期：1983-01-01 00:00:00

abstract：:The consumption of various groups of antihypertensive drugs in Spain during the period 1977-1981 has been measured by the DDD method. The total consumption of the drugs did not change much during this time. Combinations of thiazides with other hypotensives accounted for more than half the total antihypertensive drugs ...

journal_title：European journal of clinical pharmacology

authors： Capellà D,Porta M,Laporte JR

更新日期：1983-01-01 00:00:00

abstract：:To evaluate the possible effect of quinidine on digoxin bioavailability, the steady state digoxin kinetics was examined with and without concomitant quinidine therapy, in 7 cardiac patients after simultaneous administration of oral digoxin and intravenous [3H]-digoxin. In the presence of quinidine, the absorption rate...

journal_title：European journal of clinical pharmacology

authors： Pedersen KE,Christiansen BD,Klitgaard NA,Nielsen-Kudsk F

更新日期：1983-01-01 00:00:00

abstract：:The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of ...

journal_title：European journal of clinical pharmacology

authors： Callaghan JT,Tsuru M,Holtzman JL,Hunninghake DB

更新日期：1983-01-01 00:00:00

abstract：:The cleansing effects on pus and debris of streptokinase-streptodornase and of stabilized crystalline trypsin were compared in 40 patients (12 males, 28 females) with necrotic varicose or arteriosclerotic leg ulcers. Both preparations produced significant partial or total cleansing of the ulcers of necrotic material, ...

journal_title：European journal of clinical pharmacology

authors： Hellgren L

更新日期：1983-01-01 00:00:00

abstract：:The pharmacokinetics of i.v. chloramphenicol succinate and oral chloramphenicol palmitate were studied in Ethiopian children with different nutritional states. In children with kwashiorkor the plasma clearance of chloramphenicol was significantly lower than in children of normal weight (4.16 ml/min/kg versus 7.53 ml/m...

journal_title：European journal of clinical pharmacology

authors： Eriksson M,Paalzow L,Bolme P,Mariam TW

更新日期：1983-01-01 00:00:00

abstract：:The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty ...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Grennan DM,Siddiqui M

更新日期：1983-01-01 00:00:00

abstract：:Fifteen mild to moderate hypertensives were submitted to exercise testing using a bicycle ergometer with a fixed load. Heart rate, blood pressure and ECG were recorded throughout 5 min exercise and 10 min recovery. Oxygen uptake was measured during the final minute of exercise and blood glucose estimation and serum dr...

journal_title：European journal of clinical pharmacology

authors： Hackett GI,Harrison P,Kershaw S

更新日期：1983-01-01 00:00:00

abstract：:The use of cimetidine in general practice was studied in relation to the guidelines approved by the Dutch National Drug Regulatory Agency (DRA). National and regional figures showed that the frequency with which cimetidine was prescribed in general practice was greater than could be explained on the basis of approved ...

journal_title：European journal of clinical pharmacology

authors： Haayer FM,van der Werf GT,Wieringa NF,Wesseling H

更新日期：1983-01-01 00:00:00

abstract：:The biliary excretion of mebendazole has been investigated in two patients to whom it was given for the treatment of echinococcosis, although it was found to be only partly effective. Oral mebendazole was extensively metabolized and the conjugated parent substance and its metabolites were excreted in the bile. One pat...

journal_title：European journal of clinical pharmacology

authors： Witassek F,Allan RJ,Watson TR,Woodtli W,Ammann R,Bircher J

更新日期：1983-01-01 00:00:00

abstract：:The pharmacokinetics of loprazolam have been studied in eight healthy male volunteers after single and repeated 2 mg oral doses taken at night, for eight nights. The absorption and disposition of unchanged drug (HPLC-GC assay) and receptor active benzodiazepine-type materials (radioreceptor assay) were examined after ...

journal_title：European journal of clinical pharmacology

authors： Stevens LA,Bevan CD,Salmon J,Krieger J,Perianu M,LeGo A

更新日期：1983-01-01 00:00:00

abstract：:In a model of mental stress the influence of nifedipine and hydrochlorothiazide on stress-induced changes in blood pressure, heart rate, and plasma catecholamines was studied in normal persons. The drugs were used to investigate whether substances with antihypertensive but no particular sympatholytic properties were c...

journal_title：European journal of clinical pharmacology

authors： Heidbreder E,Schafferhans K,Kirsten R,Heidland A

更新日期：1983-01-01 00:00:00

abstract：:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the uri...

journal_title：European journal of clinical pharmacology

authors： Olsen H,Bredesen JE,Lunde PK

更新日期：1983-01-01 00:00:00

abstract：:Nicotine chewing gum (Nicorette 4 mg) and an identical placebo gum were administered on different days, in a double-blind cross over fashion, to 4 men, aged 25-52 years, and 4 women, aged 21-49 years, all healthy non-smokers. The subjects chewed the gum for 30 min and heart rate, blood pressure, electrocardiogram, fin...

journal_title：European journal of clinical pharmacology

authors： Nyberg G,Panfilov V,Sivertsson R,Wilhelmsen L

更新日期：1982-10-01 00:00:00

abstract：:Prazosin is a post synaptic alpha adrenergic blocker effective in hypertension, whose hypotensive effect is unaccompanied by reflex tachycardia or hyperreninemia, nor by other evidence of increased sympathetic activity. We studied the baroreceptor reflex arc as a potential mediator of these effects. Twenty-two essenti...

journal_title：European journal of clinical pharmacology

authors： Sasso EH,O'Connor DT

更新日期：1982-01-01 00:00:00

abstract：:The immediate haemodynamic and metabolic effects of acute dose of diazoxide 300 mg i.v. were studied in six healthy subjects at rest and during dynamic forearm exercise. Control periods of rest, exercise and recovery were compared with corresponding periods after drug administration. Resting forearm blood flow was alm...

journal_title：European journal of clinical pharmacology

authors： Hartling OJ,Svendsen TL,Trap-Jensen J

更新日期：1982-01-01 00:00:00

abstract：:A new data analysis approach, NON-MEM, proposed by Sheiner and Beal, has been employed to estimate the population pharmacokinetic parameters of oral mexiletine in patients treated for arrhythmias. 452 serum concentration measurements in 58 patients were available for analysis. 27 patients had congestive heart failure ...

journal_title：European journal of clinical pharmacology

authors： Vozeh S,Katz G,Steiner V,Follath F

更新日期：1982-01-01 00:00:00

abstract：:The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...

journal_title：European journal of clinical pharmacology

authors： Suzuki T,Higa S,Sakoda S,Ueji M,Hayashi A,Takaba Y,Nakajima A

更新日期：1982-01-01 00:00:00

abstract：:The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94...

journal_title：European journal of clinical pharmacology

authors： Lüscher T,Havelka J,Greminger P,Tuma J,Täuber M,Siegenthaler W,Vetter W

更新日期：1982-01-01 00:00:00

abstract：:To study the effects of enzyme induction on its pharmacokinetics, a single oral dose of the new antiarrhythmic agent mexiletine hydrochloride 400 mg was administered to 8 healthy volunteers before and after treatment with rifampicin 300 mg b.i.d. for ten days. The absorption and distribution of mexiletine were not cha...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Koivula IH,Hiltunen HA

更新日期：1982-01-01 00:00:00

abstract：:The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...

journal_title：European journal of clinical pharmacology

authors： Pagano G,Lombardi A,Ferraris GM,Imbimbo B,Cavallo Perin P

更新日期：1982-01-01 00:00:00

abstract：:We have previously shown that inhaled salbutamol further increases the bronchodilator response after the maximum effect of theophylline has been obtained in patients with severe chronic bronchitis. We now report the results of adding maximally effective doses of theophylline to the maximum response obtainable from sal...

journal_title：European journal of clinical pharmacology

authors： Barclay J,Whiting B,Addis GJ

更新日期：1982-01-01 00:00:00